Many people,
especially seniors, try to increase their intake of antioxidants to ward
off disease and aging. But could loading up on antioxidants be doing as
much harm as good?
Researchers in Kansas State University's Cardiorespiratory Exercise Laboratory" href="/topic/Cardiorespiratory+Exercise+Laboratory" >Cardiorespiratory Exercise
Laboratory have been studying how to improve oxygen delivery to the
skeletal muscle during physical activity by using antioxidants, which are
nutrients in foods that can prevent or slow the oxidative damage to the
body. Their findings show that sometimes antioxidants can impair muscle
function.
"Antioxidant is one of those buzz words right now," said Steven Copp, a
doctoral student in anatomy and physiology from Manhattan and a researcher
in the lab. "Walking around grocery stores you see things advertised that
are loaded with antioxidants. I think what a lot of people don't realize
is that the antioxidant and pro-oxidant balance is really delicate. One of
the things we've seen in our research is that you can't just give a larger
dose of antioxidants and presume that there will be some sort of
beneficial effect. In fact, you can actually make a problem worse."
Researchers in the lab study the physiology of physical activity in
health and disease through animal models. Copp and colleagues have
conducted various studies associated with how muscles control blood flow
and the effects of different doses and types of antioxidants.
Abnormalities in the circulatory system, such as those that result from
aging or a disease like chronic heart failure, can impair oxygen delivery
to the skeletal muscle and increase fatigability during physical activity,
Copp said.
The researchers are studying the effects antioxidants could have in the
process.
"If you have a person trying to recover from a heart attack and you put
them in cardiac rehab, when they walk on a treadmill they might say it's
difficult," said Kansas State professor David C. Poole. "Their muscles get
sore and stiff. We try to understand why the blood cells aren't flowing
properly and why they can't get oxygen to the muscles, as happens in
healthy individuals."
Copp said there is a potential for antioxidants to reverse or partially
reverse some of those changes that result from aging or disease. However,
Kansas State's studies have shown that some of the oxidants in our body,
such as hydrogen peroxide, are helpful to increase blood flow.
"We're now learning that if antioxidant therapy takes away hydrogen
peroxide -- or other naturally occurring vasodilators, which are compounds
that help open blood vessels -- you impair the body's ability to deliver
oxygen to the muscle so that it doesn't work properly," Poole said.
Poole said antioxidants are largely thought to produce better health,
but their studies have shown that antioxidants can actually suppress key
signaling mechanisms that are necessary for muscle to function
effectively.
"It's really a cautionary note that before we start recommending people
get more antioxidants, we need to understand more about how they function
in physiological systems and circumstances like exercise," Poole said.
Daniel Hirai, an anatomy and physiology doctoral student from Manhattan
working in the lab, said the researchers will continue to explore
antioxidants and the effects of exercise training. Their studies are
looking at how these can help individuals combat the decreased mobility
and muscle function that comes with advancing age and diseases like heart
failure.
"The research we do here is very mechanistic in nature, and down the
road our aim is to take our findings and make recommendations for diseased
and aging populations," Copp said.
The researchers have published their recent findings in several
journals, including the Journal of Applied Physiology, Respiratory
Physiology and Neurobiology, Microvascular Research, The American Journal
of Physiology and Experimental Physiology.
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